Suppression of Harmaline Tremor by Activation of an Extrasynaptic GABA<sub>A</sub> Receptor: Implications for Essential Tremor
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چکیده
منابع مشابه
Review Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor
Background: Harmaline and harmine are tremorigenic b-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature. This drug-induced action tremor has been proposed as a model of essential tremor. Here we review what is known about harmaline tremor. Methods: Using the terms harmaline and harmine on PubMed, we searched f...
متن کاملHarmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor
BACKGROUND Harmaline and harmine are tremorigenic β-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature. This drug-induced action tremor has been proposed as a model of essential tremor. Here we review what is known about harmaline tremor. METHODS Using the terms harmaline and harmine on PubMed, we searched f...
متن کاملRiluzole Ameliorates Harmaline-Induced Tremor in Rat
Introduction: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of current study was to investigate the effects of riluzole on harmaline-induced tremor in rat. Material and Methods: Four groups of Wistar rats weighing 80–100 g were injected with harmaline...
متن کاملMinocycline Mitigation of Tremor Syndrome and Defect of Cognitive and Balance Induced by Harmaline
Introduction: Minocycline has anti-inflammatory, anti-apoptotic, and anti-oxidant effects. Preclinical data suggest that minocycline could be beneficial for treating common neurological disorders, including Parkinson disease and multiple sclerosis. Methods: In this study, the effects of minocycline on harmaline-induced motor and cognitive impairments were studied in male Wistar rats. The rats ...
متن کاملRiluzole Ameliorates Harmaline-induced Tremor in Rat
INTRODUCTION Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of the present study was to investigate the effects of riluzole on harmaline-induced tremor in rat. METHODS Four groups of Wistar rats weighing 80-100 g were injected with harmaline (30 mg/ ...
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ژورنال
عنوان ژورنال: Tremor and Other Hyperkinetic Movements
سال: 2018
ISSN: 2160-8288
DOI: 10.5334/tohm.407